Correlation supersedes causation, and science can advance even without coherent models, unified theories, or really any mechanistic explanation at all. [ C. Anderson, Wired, 2008-07-16 ] First, I disagree with this statement. Second, thanks to...
Topics: adme, chemical space, clinical test, data analysis, data curation, hypothesis, ontology, theory, toxicity

{"title":"Data, models, or both?","post_url":"http:\/\/miningdrugs.blogspot.com\/2008\/08\/data-models-or-both.html","feed_url":"http:\/\/miningdrugs.blogspot.com\/feeds\/posts\/default?alt=rss","author":"joergkurtwegner","date":"2008-08-03 11:01:00","summary":"Correlation supersedes causation, and science can advance even without coherent models, unified theories, or really any mechanistic explanation at all. [ C. Anderson, Wired, 2008-07-16 ] First, I disagree with this statement. Second, thanks to..."}

== Receptors: Can't Live With 'Em, Can't Understand 'Em (In the pipeline) == At various points in my drug discovery career, I’ve worked on G-protein-coupled receptor ( GPCR ) targets. Most everyone in the drug industry has at some point.
Topics: alzheimer, amyloid, app, G-protein-coupled receptor, gpcr, NSAID, secretase

{"title":"Quotes from the neighbors (July 2008)","post_url":"http:\/\/miningdrugs.blogspot.com\/2008\/07\/quotes-from-neighbors-july-2008.html","feed_url":"http:\/\/miningdrugs.blogspot.com\/feeds\/posts\/default?alt=rss","author":"joergkurtwegner","date":"2008-07-27 12:27:00","summary":"== Receptors: Can't Live With 'Em, Can't Understand 'Em (In the pipeline) == At various points in my drug discovery career, I\u2019ve worked on G-protein-coupled receptor ( GPCR ) targets. Most everyone in the drug industry has at some point."}

" But as the influx and complexity of biological data continue to grow, so will the challenge of organizing and maintaining these databases. Fortunately, the biology community can provide an answer that will scale with the challenge: community...
Topics: bioinformatics, ecoliwiki, genmapp, gpml, pathvisio, wikipathways, wikiproteins

{"title":"WikiPathways - the challenge of community curation","post_url":"http:\/\/miningdrugs.blogspot.com\/2008\/07\/wikipathways-challenge-of-community.html","feed_url":"http:\/\/miningdrugs.blogspot.com\/feeds\/posts\/default?alt=rss","author":"joergkurtwegner","date":"2008-07-26 11:38:00","summary":"" But as the influx and complexity of biological data continue to grow, so will the challenge of organizing and maintaining these databases. Fortunately, the biology community can provide an answer that will scale with the challenge: community..."}

As posted by Noel and Rich was the Java -based AstexViewer just got LGPL ed and voila! Here it is, the Open AstexViewer for structure-based drug design. I personally was especially interested in the electron density functionality and how easy it would be.
Topics: acetylcholinesterase, astex, captopril, chemspider, java, lasso, lgpl, lisinopril, molecular modeling, openastexviewer, structural biology

{"title":"OpenAstexViewer - an open structural biology viewer","post_url":"http:\/\/miningdrugs.blogspot.com\/2008\/06\/openastexviewer.html","feed_url":"http:\/\/miningdrugs.blogspot.com\/feeds\/posts\/default?alt=rss","author":"joergkurtwegner","date":"2008-06-19 10:58:00","summary":"As posted by Noel and Rich was the Java -based AstexViewer just got LGPL ed and voila! Here it is, the Open AstexViewer for structure-based drug design. I personally was especially interested in the electron density functionality and how easy it would be."}

It was almost two months ago that David Bradley asked the question (via LinkedIn ), if science may benefit from social software? Several people responded, and especially David Crotty started a controversial discussion based on my raised points. First,...
Topics: debate, editorial process, open science, science, social software, transparent process

{"title":"Science - editorial, social, or both","post_url":"http:\/\/miningdrugs.blogspot.com\/2008\/06\/science-editorial-social-or-both.html","feed_url":"http:\/\/miningdrugs.blogspot.com\/feeds\/posts\/default?alt=rss","author":"joergkurtwegner","date":"2008-06-01 12:10:00","summary":"It was almost two months ago that David Bradley asked the question (via LinkedIn ), if science may benefit from social software? Several people responded, and especially David Crotty started a controversial discussion based on my raised points. First,..."}